Abstract
Background: Perinatal mental disorders are common, yet few robust risk factors are known. Stressful life events such as loss of a close family member due to death could serve as potential clinical predictors for which mothers develop perinatal mental disorders. This study investigated the association between bereavement and the risk of first-onset perinatal mental disorders.Method: This nationwide register-based study included 1,986,490 pregnancies in Sweden (1,097,126 mothers). The exposure was death of a family member (sibling, parent, partner or child) occurring any time before pregnancy and during the perinatal period, treated as a time-varying variable (number exposed = 276,252). The outcome consisted of first-onset mental disorders diagnosed during the pregnancy and the year after birth were identified from registers. Hazard ratios (HRs) for any mental disorder and specific disorders were estimated using Cox proportional hazards regression.Results: Loss of a family member at any time before or during the perinatal period was associated with an increased risk of any perinatal mental disorder (hazard ratio [95% confidence interval]: 1.44 [1.41, 1.48]), particularly if the loss occurred during the perinatal period (5.86 [5.62, 6.12]). The strongest associations were observed for postpartum mental disorders in relation to stillbirth (25.97 [24.60, 27.42]) or multiple losses during the perinatal period (16.92 [13.72, 20.86]). Family loss during the perinatal period was most strongly associated with stress-related disorders (16.90 [16.10, 17.75]), but also with depressive, anxiety, and psychotic disorders.Conclusions: Loss of a family member was associated with increased risks of first-onset perinatal mental disorders, particularly if the loss occurred during the perinatal period. Bereaved women may benefit from enhanced monitoring and screening for mental disorders during the perinatal period.