Abstract
BACKGROUND: Human T- lymphotropic Virus type 1 (HTLV-1) is a powerful oncovirus. In South America there is a high incidence of cases in countries such as Brazil, Peru and Colombia, mainly affecting the indigenous and Afro-descendant population. In children, the main clinical findings are dermatological manifestations followed by lung disease, opportunistic coinfections, and autoinflammatory disorders. The main target of HTLV-1 is CD4+ T lymphocytes, which are the regulators of the acquired immune response, but It’s also capable of infecting CD8+ T lymphocytes, B cells, dendritic cells and synovial cells. The purpose of this study is to describe the humoral and cellular immunological profile in pediatric patients diagnosed with HTLV-1 in a reference center in Cali, Colombia. [Figure: see text] METHODS: This is an observational, descriptive, retrospective cross-sectional study carried out between January 2017 and March 2021. [Figure: see text] RESULTS: Nineteen patients were included in this study with a median age at diagnosis of 94 months, most of them were schoolchildren (52.6%), 50% of patients had elevated B lymphocytes (CD19), and 50% of them had normal range cytotoxic T lymphocytes (CD8+) and helper T lymphocytes (CD4) (Table 1 and graph 1). None of the patients had decreases in serum immunoglobulins (IgM, IgG, IgE and IgA) (Table 2 and graph 2) [Figure: see text] CONCLUSION: HTLV-1 immunosuppression is not mediated by low levels of lymphocyte subpopulations in the pediatric population. [Figure: see text] DISCLOSURES: All Authors: No reported disclosures