Abstract
Aortitis is a rare inflammatory condition with diverse etiologies. Tuberculosis, though infrequently involved, may coexist with giant cell arteritis (GCA), sharing similar clinical features that complicate diagnosis. Their association is exceptionally rare, presenting a significant diagnostic challenge for clinicians. A 61-year-old man with no prior medical history presented with systemic and inflammatory symptoms, revealing diffuse aortitis associated with both tuberculosis and GCA, the latter confirmed by temporal artery biopsy. The rare coexistence of tuberculous aortitis and GCA poses a diagnostic challenge, requiring thorough analysis of clinical, biological, histological, and progressive findings.