Abstract
Inflammation, malignant tumors, and age-related disorders are all associated with oxidative DNA damage. 8-oxoguanine DNA glycosylase 1 (OGG1), which recognizes and repairs intracellular oxidative damage, was initially thought to play a pivotal role in cellular repair of such damage. However, a growing body of evidence now indicates that OGG1 not only participates in DNA oxidative damage repair but also possesses transcription factor activity, closely linked to the development and progression of oxidative DNA damage-related diseases. We propose that OGG1 can repair damaged DNA, while in certain diseases, OGG1 promotes transcription and exacerbates disease progression. This review discusses the mechanisms of action of OGG1 and proposes it as an emerging therapeutic target for curing the aforementioned diseases.