Abstract
Background: Sebaceous hyperplasia (SH) is a common benign condition characterized by enlarged sebaceous glands, often requiring treatment for cosmetic or symptomatic reasons. Conventional therapies include laser ablation, electrosurgery, and cryotherapy, but these may be associated with discomfort, scarring, or recurrence. High-Frequency Focused Ultrasound (HIFU) has emerged as a non-invasive alternative. This study evaluates the efficacy, safety, and patient acceptability of HIFU for the treatment of SH. Methods: Six patients with a total of 33 SH lesions underwent a single HIFU session at a frequency of 20 MHz. Lesion resolution was assessed clinically and dermatoscopically, while secondary outcomes included patient-reported pain levels and treatment-related side effects. Follow-up evaluations were conducted to determine therapeutic response and tolerability. Results: Post-treatment, 87.9% (n = 29) of lesions achieved complete resolution, while 12.1% (n = 4) demonstrated partial reduction in size. Patients reported minimal discomfort during the procedure, describing it as virtually painless. The side effect profile was favorable, with no significant adverse events recorded. Conclusions: HIFU at 20 MHz is an effective and well-tolerated treatment for SH, offering high rates of lesion clearance with minimal discomfort and a low risk of complications. These findings support the role of HIFU as a promising non-invasive alternative to traditional SH treatments, aligning with the trend toward less aggressive dermatological interventions. Further studies with larger cohorts and long-term follow-up are warranted to confirm these results.