Abstract
The relationship between the use of supplements and the presence of abdominal obesity is a topic that is currently being debated. The purpose of the present study was to evaluate the existence of such an association. The current cross-sectional investigation included a population of 9878 individuals who were the focus of the study's initial phase in the Shahedieh cohort study, conducted in Yazd, Iran. Waist circumference was measured with the help of an inflexible tape measure. In addition, the data regarding the consumption of various supplements, including multivitamins, folic acid, ferric compounds, omega 3, calcium, vitamin D, zinc, and other supplements, were collected through interviews conducted by trained interviewers. Among the entire sample, 4785 individuals (50.6%) were found to have abdominal obesity, while 4093 individuals (43.3%) reported using at least one type of supplements. In the simple regression analysis, all of the supplements, except for multivitamins and zinc, were identified as adverse factors for abdominal obesity. However, in the multivariable regression analysis, only ferric compounds remained significant as a protective factor (OR = 0.73, 95%CI: 0.57‒0.94). The findings of this study suggest that dietary supplements, particularly ferric compounds, may have implications for managing abdominal obesity. These findings could inform public health strategies by incorporating ferric compound supplementation into dietary interventions aimed at reducing abdominal obesity prevalence. Furthermore, the potential clinical application of ferric compounds highlights the need for integrating nutritional approaches in obesity management programs. However, longitudinal studies are needed to establish causal relationships and confirm the long-term effectiveness and safety of such interventions.