Abstract
Anxiety symptoms occur more frequently during adolescence and early adulthood, increasing the risk of future anxiety disorders. Neuroscientific research on anxiety has primarily focused on adulthood, employing mostly univariate approaches, discounting large-scale alterations of the brain. Indeed adolescents with trait anxiety may display similar abnormalities shown by adults in brain regions ascribed to the default mode network, associated with self-referential thinking and rumination-related processes. The present study aims to explore resting-state connectivity patterns associated with trait anxiety in a large sample of young individuals. We analyzed the rs-fMRI images of 1263 adolescents (mean age 20.55 years) and their scores on anxiety trait. A significant association between trait anxiety and resting-state functional connectivity in two networks was found, with some regions overlapping with the default mode network, such as the cingulate gyrus, the middle temporal gyri and the precuneus. Of note, the higher the trait anxiety, the lower the connectivity within both networks, suggesting abnormal self-referential processing, awareness, and emotion regulation abilities in adolescents with high anxiety trait. These findings provided a better understanding of the association between trait anxiety and brain rs-functional connectivity, and may pave the way for the development of potential biomarkers in adolescents with anxiety.