Abstract
BACKGROUND: Namibia is experiencing a generalized HIV epidemic, with 7.5% of the population living with HIV. Adolescent girls and young women (AGYW) aged 15-24 account for 28.6% of new infections annually. Various factors increase AGYW's vulnerability to HIV. To address this, Project HOPE Namibia (PHN)-led consortium implemented the PEPFAR/USAID-funded DREAMS project in Khomas, Oshikoto, and Zambezi regions from 2018 to 2023. This study estimated the AGYW population most in need of HIV prevention and assessed geographic and age-specific gaps to improve program effectiveness and efficiency. METHODS: This secondary data analysis utilized the Namibia Population-Based HIV Impact Assessment (NamPHIA) 2017, the Namibia census, and service data from the DREAMS project, which includes entry points for recruitment, screening, and enrolment. We used Python to conduct unadjusted and adjusted Poisson regression and UpSet plots for data visualization. RESULTS: Analysis of NamPHIA data revealed low HIV prevalence in 10-14-year-olds, with only Oshikoto showing a detectable rate of 2.76%, mostly attributed to perinatal HIV transmission. Of the 12 DREAMS eligibility criteria, three could be mapped to 10-14-year-olds, while all except sexually transmitted infections could be mapped for 15-19 and 20-24-year-olds. Nationally, 17.3% of 10-14-year-old AGYW, 48.0% of 15-19-year-olds, and 50% of 20-24-year-olds met at least one DREAMS eligibility criterion. Among 15-19-year-olds, a history of pregnancy, no/irregular condom use, and out-of-school status were positively associated with HIV status. For 20-24-year-olds, transactional sex was positively associated with HIV status. Overall, 62% of screened individuals were eligible, and 62% of eligible individuals enrolled. PHN screened 134% of the estimated 37,965 10-14-year-olds, 95% of the estimated 35,585 15-19-year-olds, and 57% of the 24,011 20-24-year-olds residing in the five districts where DREAMS was implemented. CONCLUSIONS: We recommend the refinement of the DREAMS eligibility criteria, particularly for AGYW 10-14, to better identify and engage those at risk of HIV acquisition through sexual transmission. For 15-19-year-olds, PHN efforts should interrogate geographic variability in entry points for recruitment and screening practices. PHN should enhance the recruitment and engagement of AGYW 20-24, with a particular focus on those engaged in transactional sex.