Abstract
INTRODUCTION: Mass casualty incidents (MCIs) present significant challenges to emergency response systems, often overwhelming healthcare resources. This article highlights the critical role of integrating postexposure prophylaxis (PEP) into emergency protocols to mitigate immediate and secondary health risks occurring due to mass casualty. The aim is to underscore the importance of PEP in MCI management and advocate for its systematic incorporation into emergency preparedness and response. METHODS: This is a perspective article drawing upon existing literature, guidelines from organizations such as UNAIDS, and expert opinion to synthesize the importance of PEP in the context of MCIs. It discusses the rationale for PEP, challenges in its implementation, particularly in resource-limited settings, and proposes strategies for its integration into emergency protocols. RESULTS: The analysis underscores that prompt PEP administration significantly reduces the risk of bloodborne pathogen transmission following potential exposure during MCIs. Effective MCI response necessitates hospital preparedness, robust Emergency Medical Services (EMS), interagency collaboration, and trained personnel. The potential for HIV transmission in crash emergencies is often overlooked, highlighting the urgent need for PEP inclusion in emergency protocols. Key recommendations include establishing robust surveillance systems, training first responders, ensuring the availability of personal protective equipment and point-of-care test kits, establishing blood bank networks, and ensuring widespread access to PEP with a low threshold for its administration. CONCLUSION: Integrating PEP into emergency response strategies is imperative for enhancing the resilience and preparedness of healthcare systems, especially in resource-constrained settings. This proactive approach can significantly reduce morbidity, mortality, and the public health burden associated with infectious disease transmission following MCIs. Therefore, the systematic incorporation of PEP into emergency protocols, supported by interagency collaboration, training, and resource allocation, is strongly recommended.