Abstract
Osteonecrosis of the femoral head is a well-recognized musculoskeletal complication of sickle cell disease (SCD) that frequently results in early joint destruction and functional disability in young patients. The coexistence of avascular necrosis and septic arthritis in SCD patients is uncommon and presents significant diagnostic and therapeutic challenges. We report the case of a 24-year-old male patient with sickle cell disease who developed septic arthritis of the hip following femoral head core decompression, ultimately requiring staged total hip arthroplasty.