Productive Infection of Human Embryonic Stem Cell-Derived NKX2.1+ Respiratory Progenitors with Human Rhinovirus

人类胚胎干细胞衍生的 NKX2.1+ 呼吸道祖细胞与人鼻病毒的有效感染

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作者:Robert A Jenny, Claire Hirst, Sue Mei Lim, Adam L Goulburn, Suzanne J Micallef, Tanya Labonne, Anthony Kicic, Kak-Ming Ling, Stephen M Stick, Elizabeth S Ng, Alan Trounson, Antonietta Giudice, Andrew G Elefanty, Edouard G Stanley

Significance

This report provides proof-of-principle experiments demonstrating, for the first time, that human respiratory progenitor cells derived from stem cells in the laboratory can be productively infected with human rhinovirus, the predominant cause of the common cold.

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