Abstract
Renalase is a pro-growth, immune-modulating protein. We examined plasma renalase concentrations in people with HIV (PWH) and people without HIV (PWoH) [N=2361]. Renalse concentrations did not differ between PWH and PWoH. However, renalase concentrations were associated with higher viral loads. Among PWH, the subset with highest renalase concentrations demonstrated higher mortality independent of viral loads (adjusted hazard ratio 1.30 [95% CI 1.03–1.64], identifying a previously unknown high-risk subset of PWH warranting further investigation.