Abstract
Rectal perforation leads to massive translocation of intestinal bacteria and enteric fluid into the peritoneal cavity, which can cause severe intra-abdominal infection and may progress to sepsis. Beyond prompt surgical intervention and drainage, proactive prevention of potential postoperative complications is critically important. This report describes the case of a patient with septic shock secondary to rectal perforation complicated by rhabdomyolysis, who was managed in our intensive care unit. During treatment, HA380 hemoperfusion was utilized as an adjunctive therapy to assist in controlling the inflammatory response and potentially mitigate the progression of acute kidney injury. Through the analysis of this clinical case, we emphasize that in patients with rectal perforation, halting the progression of sepsis, timely clearance of inflammatory cytokines, and multidimensional prevention of complications are essential components of successful management.