Abstract
Diabetic foot ulcer (DFU) represents a common and difficult-to-treat complication in diabetic patients. During the initiation and progression of DFU, the impaired energy metabolism in patients leads to a spectrum of pathological processes, including vasculopathy and neuropathy. Through pseudo-hypoxia, oxidative stress, and chronic inflammation, the energy metabolism disorders can result in metabolic reprogramming and functional dysregulation of immune and reparative cells, ultimately leading to ulcer formation and delayed wound healing. This review summarized the intrinsic relationship between common energy substance metabolism disorders in DFU patients and the onset and progression of DFU, the impact of energy metabolism disorders on wound cells in DFU, as well as the foundational and clinical research progress on targeted energy metabolism therapy for DFU.