Early Markers for Dementia in the Intellectual Disability Population: A Systematic Literature Review

智力障碍人群痴呆症早期标志物:系统性文献综述

阅读:1

Abstract

BACKGROUND: Adults with intellectual disability, especially those with Down syndrome, are at increased risk of dementia. Whilst memory decline is often considered the earliest symptom, emerging research indicates decline in language, executive function, and non-cognitive domains may also occur early, potentially before memory changes. METHOD: A systematic review using narrative synthesis was conducted to evaluate recent literature on early symptoms of dementia and the trajectory of decline in people with intellectual disabilities and Down syndrome. RESULTS: Eighteen peer-reviewed studies met the inclusion criteria. Early decline was observed across multiple domains, with memory and executive function frequently identified as sensitive to early decline. Attention, mobility, and behaviour were also commonly reported. CONCLUSION: The findings suggest that early dementia symptoms extend beyond memory decline, highlighting the need to broaden current assessment guidelines. Further research is required to address methodological limitations and improve early detection in this population.

特别声明

1、本页面内容包含部分的内容是基于公开信息的合理引用;引用内容仅为补充信息,不代表本站立场。

2、若认为本页面引用内容涉及侵权,请及时与本站联系,我们将第一时间处理。

3、其他媒体/个人如需使用本页面原创内容,需注明“来源:[生知库]”并获得授权;使用引用内容的,需自行联系原作者获得许可。

4、投稿及合作请联系:info@biocloudy.com。