Abstract
BACKGROUND AND PURPOSE: Proton arc therapy (PAT) is an emerging modality delivering continuously rotating proton beams. Current PAT planning approaches are time-consuming, making them unsuitable for online adaptation. This study proposes an accelerated workflow for adapting PAT plans. MATERIALS AND METHODS: The proposed workflow transfers spots from initial computed tomography (CT) to the CT of the day, updates energy layers considering the initial pattern, and re-optimizes selected transferred spots based on their initial weights and impact on the objective function.A retrospective study was conducted on five head and neck patients who underwent plan adaptation on a repeated CT. PAT plans were generated with two different methods on the repeated CT: reference, created de novo, and smart-adapted, generated with the proposed adaptive workflow. Robust optimization was performed for all plans. RESULTS: Smart-adapted plans achieved similar mean dose to organs at risk as the reference: the largest median increase of mean dose was 1.9 Gy to the mandible; the median of maximum dose to spinal cord was 0.5 Gy lower for the smart-adapted plans. The median target coverage, i.e. D(98), to primary tumor and nodes of smart-adapted plans decreased by 0.2 and 0.4 Gy for the nominal case, and 0.4 and 0.6 Gy for the worst-case scenario; all smart-adapted plans met clinical objectives. The smart-adaptation method reduced average planning time from 19184 s to 5626 s, a 3.4-fold improvement. CONCLUSIONS: Smart-adapted plans achieve similar plan quality to the reference method, while significantly reducing plan generation time for new patient anatomy.