Abstract
PURPOSE: This study aimed to investigate the effects of a 12-week multimodal motor-cognitive and resistance training (MMI) compared to a unimodal resistance training intervention (UMI) on static and dynamic visual function in glaucoma (GLA) patients and healthy controls (HC). METHODS: Fifteen GLA and 24 age-matched HC participated in this randomized, controlled longitudinal pilot study. Visual function was assessed using clinical parameters and on a treadmill (TM) while standing (static, S(0)) as well as during walking at 3.5 km/h (S(3.5)) and a self-preferred speed (S(Self)). The following outcomes were measured pre and post 12-weeks of intervention (MMI or UMI): (a) standard clinical measures and (b) TM-related measures, i.e.: 1) best-corrected visual acuity without (VA(S)) and with crowding (VA(C)); 2) visual field sensitivity (VF); and 3) contrast sensitivity (CS). A 4-factorial repeated-measures ANOVA (SPEED [S(0); S(3.5); S(Self)] × TIME [pre; post] × INTERVENTION [UMI; MMI] × GROUP [GLA; HC]) was applied to determine significant interaction effects (p ≤ 0.05) and the effect size partial-eta-squared was calculated. RESULTS: Post-interventional improvement of visual function was absent or minor. Only the main effect of TIME (visual acuity; p = 0.024) and a TIME × INTERVENTION interaction (foveal sensitivity; p = 0.039) were found for standard clinical measures. For S(0) vs. S(3.5) small effects appeared in post-hoc comparisons, but TIME and TIME × SPEED just failed to reach significance for CS (p = 0.059) and VA(s) (p = 0.052), respectively. No GROUP interactions were observed. CONCLUSION: While trends were evident in this pilot study, the effect of the 12-week interventions on visual function was non-significant and, especially for TM-walking, largely independent of group and intervention type. In future studies, a greater sample size, with more advanced GLA cases, should be included to probe for significant visual function differences between groups and intervention types.