Abstract
B-cell cutaneous lymphoid hyperplasia (CLH), or B-cell pseudolymphoma, is a benign lymphoid proliferative disorder that can mimic cutaneous lymphoma. This case describes a rare instance of amlodipine-induced B-cell pseudolymphoma in a 64-year-old woman. The patient presented with itchy papules and nodules on her neck and arms, occurring shortly after starting amlodipine for hypertension. Clinical examination and punch biopsies revealed lymphoid follicles with B-cell predominance. Gene rearrangement studies were negative for clonality, supporting a benign process. The patient's reassuring clinical presentation, medication history, immunohistochemical staining and gene rearrangement analysis led to a diagnosis of B-cell CLH. Following the discontinuation of amlodipine lesions showed slow regression. Prior reports have described amlodipine-associated T-cell lymphoma but the literature lacks reports of amlodipine-induced B-cell pseudolymphoma. The diagnostic challenge lies in distinguishing pseudolymphoma from true lymphoma, emphasizing the importance of history, histopathological evaluation and clinical correlation.