Abstract
We present a case of a pseudosarcomatous stromal proliferation of the ampullary and duodenal mucosa and its treatment in an asymptomatic 61-year-old man with a history of prostate adenocarcinoma and carotid paraganglioma. There is a modicum of literature describing these cases and treatment involving the gastrointestinal tract. The intricacy of diagnosis can further complicate management which necessitates the need for discussion between the clinician and the pathologist to avoid unnecessary invasive intervention. Our example of a pseudosarcoma involving the ampullary and duodenal mucosa and its treatment is unprecedented, therefore, should serve as an example for similar cases.