Abstract
Diabetic foot ulcer (DFU), a severe complication of diabetes, poses a significant clinical challenge due to its slow healing and high recurrence rate. In recent years, with the rapid advancement of regenerative medicine, the treatment strategies for DFU have undergone a revolution. This review systematically reviews the application status of regenerative biotechnologies in DFU treatment, with a specific focus on recent progresses in key areas including stem cell therapy, biomaterials engineering, and growth factor-based therapeutics. It aims to provide a scientific foundation for future research directions and clinical translation.