Abstract
BACKGROUND: Pulmonary tuberculosis (PTB) may have an autoimmune component. However, the cause of autoimmune diseases associated with PTB remains unclear. We performed a Mendelian randomization (MR) study to determine the causal genetic connections between liability to autoimmune diseases (AIDs) and PTB. METHODS: After rigorous assessment, potential candidate SNPs for 10 AIDs and PTB were extracted from GWAS datasets. Three common MR approaches-inverse variance weighted (IVW), weighted median, and MR-Egger-were employed to assess causal relationships. To ensure the robustness of the findings, sensitivity analyses were performed to evaluate the stability of the results by estimating the heterogeneity and pleiotropy. RESULTS: Our MR analysis indicated no discernible causal genetic connections between the seven AIDs, including rheumatoid arthritis (RA), asthma, Crohn's disease (CD), systemic lupus erythematosus (SLE), psoriasis (PsO), multiple sclerosis (MS), ankylosing spondylitis (AS), and PTB (all P>0.05). Interestingly, inflammatory bowel disease (IBD; OR, 0.967; 95% CI: 0.941-0.994, P=0.015), celiac disease (CeD; OR, 0.944; 95% CI: 0.917-0.972, P<0.001), and primary sclerosing cholangitis (PSC; OR, 0.935; 95% CI: 0.877-0.997, P=0.041) were significantly associated with a decreased risk of PTB. The sensitivity analyses confirmed the robustness of the results. CONCLUSION: Our MR observations collectively highlight that genetically predicted IBD, CeD, and PSC may be protective factors against PTB. However, there was no evidence of causal ramifications between the other seven AIDs (RA, asthma, CD, SLE, PsO, MS, and AS) and PTB, implying that unmeasured confounders or shared genetic structures may be the cause of the reported epidemiological associations.