Abstract
BACKGROUND: The interaction between fine particulate matter (PM2.5) and genetic factors can lead to epigenetic modifications, potentially increasing the risk of SLE development. However, the impact of PM2.5 on incident SLE development remains unelucidated. This study investigated the effects of year-to-year variations in PM2.5 exposure on incident SLE risk in Taiwanese adults. METHODS: In this longitudinal study, we followed up 268 254 adults from the Taiwan MJ cohort (2005-2017) for 9.8 years to identify incident SLE cases, ascertained from patients' clinical and laboratory reports. Residential address-specific annual PM2.5 concentrations were obtained from Taiwan Air Quality-Monitoring sites. We employed a time-dependent Cox regression model, considering death as a competing risk, to assess the impact of year-to-year variations of PM2.5 exposure on SLE development. RESULTS: During 2 628 889 person-years of follow-up, 151 (0.1%) individuals developed new-onset SLE. Participants with higher levels of PM2.5 exposure (per 5 μg/m(3) increase) had significantly higher risk of incident SLE (adjusted HR 3.35; 95% CI 2.94 to 3.82). We observed a significant positive linear relation between increasing level of PM2.5 exposure and higher risk of incident SLE in all individual subgroups after stratifying study subjects by age and sex (p<0.001). CONCLUSION: PM2.5 exposure emerged as a risk factor for incident SLE. Air pollution mitigation strategies should be considered as a preventive measure for SLE.