Conclusions
There is evidence that platelet activation in patients with PAOD is related to the vascular disease and is dependent on the severity of inflammation.
Methods
Subjects were studied on a single occasion. C-reactive protein (CRP) and two indexes of in vivo platelet activation were measured - the urinary excretion of 11-dehydrothromboxane (TX) B(2) by immunoassay and circulating platelet-monocyte aggregates (PMAs) by flow cytometry.
Results
Plasma PMAs and urinary 11-dehydro-TXB(2) were significantly increased in PAOD patients compared with controls (P<0.01 for all). A positive correlation between 11-dehydro-TXB(2) and CRP was found in the study population (r(s)=0.63, P<0.001). Using logistic regression analysis, CRP was the only independent correlate of 11-dehydro-TXB(2) (β(CRP)=11.9, P<0.01), whereas only the presence of PAOD was an independent predictor of high PMA levels (β(PAOD)=13.7, P=0.001). Chronic administration of acetylsalicylic acid reduced 11-dehydro-TXB(2), but not PMA and CRP. Conclusions: There is evidence that platelet activation in patients with PAOD is related to the vascular disease and is dependent on the severity of inflammation.