Predicting Outcome in Head and Neck Cancer: miRNAs with Potentially Big Effects

A five-miRNA signature for human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) identifies patients at risk for inferior outcomes. Combining established clinical variables with this novel miRNA signature affords an opportunity to personalize and intensify treatment strategies in this high-risk patient population.See related article by Hess et al., p. 1505.