Abstract
The atherogenic index of plasma (AIP) is a significant indicator of lipid levels. This study aimed to investigate the association between psoriasis and AIP in adults. The association between AIP and psoriasis was investigated using multivariate logistic regression, and smoothing curve fitting utilizing data from the National Health and Nutrition Examination Survey 2009 to 2014. Subgroup analysis and interaction tests were employed to investigate whether this relationship was stable across populations. The final sample included 8177 participants, representing approximately 60 million people in the US. Psoriasis among the AIP groups (quartile, Q1-Q4) was statistically significant (P < .05). In the minimally adjusted model, each 1-unit increase in AIP was associated with a 44% increase in the risk of developing psoriasis [1.44 (1.01, 2.20)]. Participants in the highest quartile of AIP had a 40% higher risk of developing psoriasis than those in the lowest quartile [1.40 (1.05, 2.10)]. In the male group, the risk of developing psoriasis increased by 0.86 points per 1 unit increase in AIP. AIP is positively associated with psoriasis in US adults. Our findings imply that AIP improves psoriasis prevention in the general population.