Abstract
Beans, vegetables, fruits, and mushrooms offer a delightful array of fragrances and an abundance of nutrients, including essential vitamins, minerals, protein rich in vital amino acids, and omega-3 fatty acids. However, they may also contain lectins, carbohydrate-binding proteins with potential health risks. While some lectins exhibit stability and resistance to digestion, posing threats to gastrointestinal integrity and immune function, others, such as those from butterfly peas and pink bauhinia, show immunomodulatory properties that could bolster immune responses. While some lectins, such as phytohemagglutinin, have been associated with inflammatory responses and autoimmune disorders, others, such as wheat lectin, have shown potential benefits in nutrient absorption. Additionally, mushroom lectins, while generally nontoxic, exhibit immunomodulatory properties with implications for immune health. Despite their potential benefits, challenges remain in understanding lectin dosages, administration routes, and mechanisms of action. Further research is needed to elucidate the intricate roles of dietary lectins in immune function and autoimmune disorders. This review surveys the immunomodulatory effects of dietary lectins from plants and mushrooms, shedding light on their mechanisms of action. From inflammation modulation to potential autoimmune implications, the diverse roles of dietary lectins have been explored, highlighting avenues for future investigations and therapeutic exploration.