Eosinophil extracellular traps in respiratory ailment: Pathogenic mechanisms and clinical translation

嗜酸性粒细胞胞外陷阱在呼吸系统疾病中的作用:致病机制和临床转化

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Abstract

BACKGROUND: Eosinophilic extracellular traps (EETs) are reticular complexes comprising deoxyribonucleic-Acid (DNA) fibers and granule proteins. AIMS: EETs play a crucial role in antimicrobial host responses and are pathogenic when overproduced or under degraded. EETs created by eosinophils appear to enable vital immune responses against extra-cellular pathogens, nevertheless, trap overproduction is evident in pathology. MATERIALS & METHODS: As considerably research is performed, new data affirmed that EETs can alter the outcome of respiratory ailment. RESULTS: We probe into the disclosure and specificity of EETs produced in reaction to various stimuli and propose a role for those frameworks in ailment pathogenesis and the establishment of chronic, unresolved inflammation. DISCUSSION: Whether EETs can be used as a prospective brand-new target for the diagnosis, treatment and prognosis of respiratory ailments is a scientific theme worth studying. CONCLUSION: We probe into the disclosure and specificity of EETs produced in reaction to various stimuli and propose a role for those frameworks in ailment pathogenesis and the establishment of chronic, unresolved inflammation.

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