Primary oral histoplasmosis in an immunocompetent host masquerading as malignancy

Histoplasma capsulatum is known to cause deep mycotic infections, the primary site being pulmonary, and may disseminate in immunosuppressed patients. Oral presentation is usually a part of disseminated disease however may rarely occur as an isolated event. Extensive literature search has shown that only 17 cases of primary oral histoplasmosis in immunocompetent hosts have been reported from India to date. We hereby report a rare case of primary oral histoplasmosis in a middle-aged, non-diabetic, and HIV-negative patient masquerading as malignancy.