Abstract
OBJECTIVE: To review the application of urine derived stem cells (USCs) in regeneration of musculoskeletal system. METHODS: The original literature about USCs in the regeneration of musculoskeletal system was extensively reviewed and analyzed. RESULTS: The source of USCs is noninvasive and extensive. USCs express MSCs surface markers with stable proliferative and multi-directional differentiation capabilities, and are widely used in bone, skin, nerve, and other skeletal and muscle system regeneration fields and show a certain repair capacity. CONCLUSION: USCs from non-invasive sources have a wide application prospect in the regeneration of musculoskeletal system, but the definite biological mechanism of its repair needs further study.