Efficient synthesis of ether phosphonates using trichloroacetimidate and acetate coupling methods

利用三氯乙酰亚胺酯和乙酸酯偶联法高效合成醚膦酸酯

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Abstract

A series of ether phosphonates have been prepared by trichloroacetimidate and acetate coupling methods. Trichloroacetimidates or acetates were treated with primary and secondary alcohols as O-nucleophiles in the presence of catalytic TMSOTf to afford 21 examples of diethyl alkyloxy(substitutedphenyl)methyl phosphonates via C-O bond formation in 55-90% yields and short reaction time.

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