In vitro and in vivo evaluations of mechanical properties, biocompatibility and osteogenic ability of sintered porous titanium alloy implant

对烧结多孔钛合金植入物的力学性能、生物相容性和成骨能力进行体外和体内评价

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Abstract

A new sintering technique using Ti(6)Al(4)V powder suspension was performed to prepare porous Ti(6)Al(4)V alloys. The porous alloys could be fabricated with different porosities and pore sizes by controlling the quantity and size of spacer particles added to the Ti(6)Al(4)V powder. The characteristics and biological properties of the porous Ti(6)Al(4)V with two different porosities were evaluated by mechanical tests, cell tests and implantation. Dense Ti(6)Al(4)V was used as the control. Compared with the control group, the porous Ti(6)Al(4)V showed good biocompatibility and osteogenic ability, which makes this type of porous alloy a good prospective material for biomedical application. And compared with 50% porosity, the alloy with 75% porosity had the optimal mechanical properties, and suitable pore size and porosity, which allowed more bone ingrowth.

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