Effect of intermittent inspiratory leaks on measurement of lung clearance index using nitrogen and sulfur hexafluoride

Even small air leaks can have a significant impact on LCI measured using N(2). This is particularly the case for leaks that occur towards the end of washout. In contrast, leaks generally have a much smaller impact on LCI measured by SF(6). http://ow.ly/az7b30lG5Ku.