Abstract
Varioliform gastritis (VG) is a rare chronic gastritis characterized by mucosal protrusions with central depressions, typically found in the stomach. This paper discusses the first reported case of VG extending into the duodenum, involving a 68-year-old immunocompromised patient with a complex medical history, including prostate cancer and multiple comorbidities. The diagnosis was complicated by the presence of Helicobacter pylori, which was treated successfully with eradication therapy consisting of amoxicillin and clarithromycin along with omeprazole. Highlighting the potential for VG to affect areas beyond the stomach, this case underscores the importance of considering VG in patients with unexplained hypoalbuminemia and gastrointestinal symptoms.