Abstract
BACKGROUND: Quantitative parametric mapping is an increasingly important tool for noninvasive assessment of chronic liver disease. Conventional parametric mapping techniques require multiple breath-held acquisitions and provide limited anatomic coverage. PURPOSE: To investigate a multi-inversion spin and gradient echo (MI-SAGE) technique for simultaneous estimation of T(1), T(2), and T(2)* of the liver. STUDY TYPE: Prospective. SUBJECTS: Sixteen research participants, both adult and pediatric (age 17.5 ± 4.6 years, eight male), with and without known liver disease (seven asymptomatic healthy controls, two fibrotic liver disease, five steatotic liver disease, and two fibrotic and steatotic liver disease). FIELD STRENGTH/SEQUENCE: 1.5 T, single breath-hold and respiratory triggered MI-SAGE, breath-hold modified Look-Locker inversion recovery (MOLLI, T(1) mapping), breath-hold gradient and spin echo (GRASE, T(2) mapping), and multiple gradient echo (mGRE, T(2)* mapping) sequences. ASSESSMENT: Agreement between hepatic T(1), T(2), and T(2)* estimated using MI-SAGE and conventional parametric mapping sequences was evaluated. Repeatability and reproducibility of MI-SAGE were evaluated using a same-session acquisition and second-session acquisition. STATISTICAL TESTS: Bland-Altman analysis with bias assessment and limits of agreement (LOA) and intraclass correlation coefficients (ICC). RESULTS: Hepatic T(1), T(2), and T(2)* estimates obtained using the MI-SAGE technique had mean biases of 72 (LOA: -22 to 166) msec, -3 (LOA: -10 to 5) msec, and 2 (LOA: -5 to 8) msec (single breath-hold) and 36 (LOA: -43 to 120) msec, -3 (LOA: -17 to 11) msec, and 4 (LOA: -3 to 11) msec (respiratory triggered), respectively, in comparison to conventional acquisitions using MOLLI, GRASE, and mGRE. All MI-SAGE estimates had strong repeatability and reproducibility (ICC > 0.72). DATA CONCLUSION: Hepatic T(1), T(2), and T(2)* estimates obtained using an MI-SAGE technique were comparable to conventional methods, although there was a 12%/6% for breath-hold/respiratory triggered underestimation of T(1) values compared to MOLLI. Both respiratory triggered and breath-hold MI-SAGE parameter maps demonstrated strong repeatability and reproducibility. LEVEL OF EVIDENCE: 1 TECHNICAL EFFICACY: Stage 2.