Abstract
BACKGROUND: Natural compounds rich in secondary metabolites have gained attention as alternative therapies for wound healing due to their potential advantages over conventional treatments. Pleurotus ostreatus mushrooms have been identified for their wound-healing properties, including promoting neovascularization, epithelialization, and collagen synthesis. MATERIAL AND METHODS: This study aimed to investigate the wound-healing properties of different doses of topical Extract of Pleurotus ostreatus in albino mice using an excisional wound model. The experimental design involved administering various concentrations of the extract to evaluate its effects on wound closure and histopathological and immunohistochemical parameters. RESULTS: The results revealed significant wound closure and improvements in histopathological and immunohistochemical parameters in mice treated with Pleurotus ostreatus extract. These findings suggest the potential of Pleurotus ostreatus extract as a viable wound healing agent. CONCLUSION: Pleurotus ostreatus extract demonstrates promising wound-healing capabilities, including promoting wound closure and enhancing histopathological and immunohistochemical parameters in albino mice. Further research is warranted to explore its full therapeutic potential and mechanism of action in wound healing.