Abstract
BACKGROUND: Our previous studies suggested that bone mineral density (BMD) correlated with the severity of chronic heart failure (HF) as classified by the New York Heart Association (NYHA) and that blood routine test (BRT)-based biomarkers, including hemoglobin, red blood cells (RBCs), lymphocytes, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and systemic immune-inflammation index, were significantly related with BMD in general population. OBJECTIVE: This work aimed to evaluate the relationship between BRT-based biomarkers and BMD in elderly patients with chronic HF. METHODS: It was a retrospective study. BRT and BMD were measured on the same day. Chi-square analysis and 1-way analysis of variance or the Wilcoxon rank-sum test were used to compare categorical variables and continuous variables, respectively. Correlation analysis was performed by the Spearman correlation test. RESULTS: A total of 1049 participants were enrolled. Hemoglobin, RBCs, white blood cells, neutrophils, monocytes, eosinophils, lymphocyte-to-monocyte ratio, and systemic immune-inflammation index were significantly different among different NYHA groups. The Spearman correlation test showed that lumbar vertebrae 2-4 (L2-L4) BMD was closely related to hemoglobin and RBC, and that femoral neck BMD was also significantly correlated with hemoglobin and RBC, white blood cells, neutrophils, monocytes, and platelets. Furthermore, stratified analysis in different NYHA classes demonstrated, only in NYHA class I and II groups, hemoglobin was significantly related to L2-L4 and femoral neck BMD. CONCLUSION: BRT-based biomarkers were significantly different among different NYHA groups, which deserves further investigation and application in the future.