Abstract
INTRODUCTION: Perivalvular abscess in native valve infective endocarditis (IE) is associated with significantly increased mortality. CASE DESCRIPTION: Herein, we report a 29 year old Indian male who presented with culture negative IE with perivalvular abscess and severe mitral regurgitation requiring mitral valve replacement. DISCUSSION: Initial approach is very difficult in terms of when IE presents as culture negative. This case highlights the important role of echocardiography in the management of culture negative IE.