Low ambient oxygen prevents atherosclerosis

低环境氧含量可预防动脉粥样硬化

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作者:Ju-Gyeong Kang, Ho Joong Sung, Marcelo J Amar, Milton Pryor, Alan T Remaley, Michele D Allen, Audrey C Noguchi, Danielle A Springer, Jaeyul Kwon, Jichun Chen, Ji-hoon Park, Ping-yuan Wang, Paul M Hwang

Key messages

Chronic low ambient oxygen exposure decreases atherosclerosis in mice. Anti-inflammatory cytokine IL-10 levels are increased by low ambient O2. This is consistent with the established role of HIF-1α in IL10 transactivation. Absence of IL-10 results in the loss of the anti-atherosclerosis effect of low O2. This mechanism may contribute to decreased atherosclerosis at high altitudes.

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