Abstract
OBJECTIVE: To evaluate the impact of a history of gestational trophoblastic disease on pregnancy outcomes in in vitro fertilization-embryo transfer procedures(IVF-ET) and to utilize logistic regression to analyze potential risk factors influencing re-pregnancy outcomes among women with GTD histories undergoing IVF-ET. METHODS: This retrospective cohort study collected data from patients with a history of GTD who underwent IVF-ET at the hospital from January 2018 to January 2023. The study group comprised 27 women with a history of GTD. A control group of 54 women, matched at a 1:2 ratio, without a GTD history, was selected from those who underwent IVF-ET during the same period at the same hospital. Statistical analyses were employed to compare baseline characteristics, embryological parameters, and pregnancy outcomes between the two groups. RESULTS: The study group exhibited significantly lower endometrial thickness (EMT) during the mid-luteal phase of the natural menstrual cycle, reduced EMT on the day of embryo transfer (ET), and a decreased blastocyst formation rate compared to the control group (p < 0.05). Furthermore, the study group had a higher number of uterine curettages prior to transfer, an increased rate of discarded embryos, and higher total sperm motility (PR + NP) in their spouses (p < 0.05). Logistic regression analysis revealed that a history of GTD does not significantly affect pregnancy outcomes post-IVF-ET. CONCLUSION(S): A history of GTD does not significantly influence pregnancy outcomes following IVF-ET. Therefore, patients with a GTD history and their physicians can approach the IVF-ET process with less anxiety and adopt a more positive and rational outlook.