Abstract
Background and Objectives: Dermoscopy is a non-invasive clinical tool that allows for the in vivo visualization of pigmented and non-pigmented structures in the epidermis and the papillary dermis. The standard handheld dermoscopy offers a magnification of 10×, whereas the videodermatoscopes can obtain a magnification of up to 140×. Recently, a new method called magnified dermoscopy was introduced, in which a magnification of 400× can be achieved. Materials and Methods: This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines. Comprehensive research was conducted using the PubMed database on 9 June 2025, using the following keywords: "high magnification" or "super high magnification" or "optical super high magnification" or "400×", and "dermoscopy" or "dermatoscopy". Results: From a total of 237 records retrieved, 25 were found to be suitable for this review, and consisted of: four prospective studies, three retrospective studies, six case series, ten case reports and two image letters. Conclusions: This review summarizes the current knowledge on magnified dermoscopy, compiling existing data and exploring future perspectives for this emerging non-invasive diagnostic method.