Abstract
SclerEDEMA is a rare condition marked by diffuse skin thickening, often confused with sclerODERMA. It is linked with infections, malignancies, and diabetes. Although scleredema is associated with hematologic malignancies like multiple myeloma, it has not been reported with breast cancer, as suspected in this patient. We present a case of a patient diagnosed with scleredema, confirmed through skin biopsy. Subsequent cancer screenings identified a 6 mm breast nodule, which was confirmed as grade 3 ductal carcinoma. This newfound association between scleredema and breast cancer highlights the importance of vigilant health maintenance and regular cancer screenings in these patients.