Abstract
Pancreatic gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors that present significant diagnostic and treatment challenges due to their unusual location and vague symptoms. This report details an unusual case involving a male in the seventh decade of life who experienced obstructive jaundice resulting from a pancreatic GIST situated in the pancreaticoduodenal groove. Diagnosis was confirmed through imaging, histopathological analysis, and immunohistochemical studies. The patient received treatment with imatinib, which led to notable clinical improvement and considerable tumor reduction.