Abstract
BACKGROUND: Multiple cystic brain metastases are a rare form of cancer dissemination and usually originate from adenocarcinomas of the lung and breast. Managing these lesions is challenging, and cyst drainage plays an essential role in reducing intracranial pressure. This article presents a case of multiple cystic brain metastases from lung adenocarcinoma. CASE PRESENTATION: A 40-year-old female with a two-year history of stage IV lung adenocarcinoma presented with debilitating progressive neurologic symptoms. Imaging studies showed multiple cystic lesions on brain MRI most consistent with brain metastases. She underwent a craniotomy to drain the biggest cysts, followed by whole-brain radiotherapy (WBRT). The patient experienced dramatic alleviation of symptoms. Following a year of follow-up, she had no neurological symptoms. CONCLUSION: Despite the rarity of cystic brain metastases, these lesions should be ruled out in case of signs of increased intracranial pressure in a patient with a history of malignant disease.