Lophine analogues as fluorophores for selective bioimaging of the endoplasmic reticulum

The design of small-molecule fluorescent probes for labelling the endoplasmic reticulum (ER) revolves around a well-established albeit limited group of structural architectures. Here, we synthesized new fluorescent lophines in one step in high-temperature water (HTW) and explored their application as dyes for selective bioimaging of the ER.