Abstract
BACKGROUND: Substantial gaps exist in the neuroprognostication of cardiac arrest patients who remain comatose after the restoration of spontaneous circulation. Most studies focus on predicting survival, a measure confounded by the withdrawal of life-sustaining treatment decisions. Severe cerebral edema (SCE) may serve as an objective proximal imaging-based surrogate of neurologic injury. METHODS: We retrospectively analyzed data from 288 patients to automate SCE detection with machine learning (ML) and to test the hypothesis that the quantitative values produced by these algorithms (ML_SCE) can improve predictions of neurologic outcomes. Ground-truth SCE (GT_SCE) classification was based on radiology reports. RESULTS: The model attained a cross-validated testing accuracy of 87% [95% CI: 84%, 89%] for detecting SCE. Attention maps explaining SCE classification focused on cisternal regions (p < 0.05). Multivariable analyses showed that older age (p < 0.001), non-shockable initial cardiac rhythm (p = 0.004), and greater ML_SCE values (p < 0.001) were significant predictors of poor neurologic outcomes, with GT_SCE (p = 0.064) as a non-significant covariate. CONCLUSION: Our results support the feasibility of automated SCE detection. Future prospective studies with standardized neurologic assessments are needed to substantiate the utility of quantitative ML_SCE values to improve neuroprognostication.