Abstract
Mild cognitive impairment (MCI) is a neuropsychological syndrome that is characterized by cognitive impairments. It typically affects adults 60 years of age and older. It is a noticeable decline in the cognitive function of the patient, and if left untreated it gets converted to Alzheimer's disease (AD). For that reason, early diagnosis of MCI is important as it slows down the conversion of the disease to AD. Early and accurate diagnosis of MCI requires recognition of the clinical characteristics of the disease, extensive testing, and long-term observations. These observations and tests can be subjective, expensive, incomplete, or inaccurate. Electroencephalography (EEG) is a powerful choice for the diagnosis of diseases with its advantages such as being non-invasive, based on findings, less costly, and getting results in a short time. In this study, a new EEG-based model is developed which can effectively detect MCI patients with higher accuracy. For this purpose, a dataset consisting of EEG signals recorded from a total of 34 subjects, 18 of whom were MCI and 16 control groups was used, and their ages ranged from 40 to 77. To conduct the experiment, the EEG signals were denoised using Multiscale Principal Component Analysis (MSPCA), and to increase the size of the dataset Data Augmentation (DA) method was performed. The tenfold cross-validation method was used to validate the model, moreover, the power spectral density (PSD) of the EEG signals was extracted from the EEG signals using three spectral analysis methods, the periodogram, welch, and multitaper. The PSD graphs of the EEG signals showed signal differences between the subjects of control and the MCI group, indicating that the signal power of MCI patients is lower compared to control groups. To classify the subjects, one of the best classifiers of deep learning algorithms called the Bi-directional long-short-term-memory (Bi-LSTM) was used, and several machine learning algorithms, such as decision tree (DT), support vector machine (SVM), and k-nearest neighbor (KNN). These algorithms were trained and tested using the extracted feature vectors from the control and the MCI groups. Additionally, the values of the coefficient matrix of those algorithms were compared and evaluated with the performance evaluation matrix to determine which one performed the best overall. According to the experimental results, the proposed deep learning model of multitaper spectral analysis approach with Bi-LSTM deep learning algorithm attained the highest number of correctly classified samples for diagnosing MCI patients and achieved a remarkable accuracy compared to the other proposed models. The achieved classification results of the deep learning model are reported to be 98.97% accuracy, 98.34% sensitivity, 99.67% specificity, 99.70% precision, 99.02% f1 score, and 97.94% Matthews correlation coefficient (MCC).