Conclusion
Boron nitride nanotubes and curcumin had cytotoxic effects and cause DNA damage on CD34+ cells, HeLa and V79 cells at several concentrations, probably because of increased ROS level. However, there were not concentration - dependent effect and there were controversial toxicity results of the studied cell lines. Its mechanism needs to be enlightened by further analysis for potential targeted drug development. Graphical abstract.
Methods
The possible cytotoxic and DNA damaging effects of boron nitride nanotubes and curcumin on CD34+ cells, HeLa and V79 cells were evaluated by MTT assay and Comet assay, respectively.