Abstract
During synthesis, mRNA undergoes a number of modifications such as capping, splicing and polyadenylation. These processes are coupled with the orderly deposition of the TREX complex on the mRNA and subsequent recruitment of the NXF1-P15 heterodimer which stimulates the nuclear export of mature mRNAs. mRNAs also undergo a number of internal modifications, the most common of which is the N(6)‑methyladenosine (m(6)A) modification. In this review we discuss the recent evidence of coupling between the m(6)A modification, RNA processing and export.