Abstract
Alzheimer's disease and oxidative stress are connected. In the present communication, we report the use of a Mn(II) -based superoxide dismutase (SOD) mimic ([Mn(II) (L)](+) , 1(+) ) as a pro-drug candidate to target Cu(II) -associated events, namely, Cu(II) -induced formation of reactive oxygen species (ROS) and modulation of the amyloid-β (Aβ) peptide aggregation. Complex 1(+) is able to remove Cu(II) from Aβ, stop ROS and prevent alteration of Aβ aggregation as would do the corresponding free ligand LH. Using 1(+) instead of LH in further biological applications would have the double advantage to avoid the cell toxicity of LH and to benefit from its proved SOD-like activity.