Abstract
PURPOSE: New frequency correction methods are required to achieve the accurate measurement of frequency drifts in MRS and MRSI. We present a prospective frequency correction method with outer volume suppression (OVS)-based localization and selective water excitation for effective frequency correction with better SNR improvement compared to other techniques. METHODS: An OVS-localized navigator was developed to prospectively correct frequency drifts during MRS and MRSI measurements. The performance of the navigator was tested on the human brain and a solution phantom for frequency drifts induced by head motion or gradient heating by a preceding DWI experiment at 3T. RESULTS: The OVS-localized navigator could accurately track motion-induced frequency drifts with an RMS error of 0.5 Hz. The SNR of MRS signals was not affected by use of the OVS-localized navigator when compared with and without the navigator (P > 0.05). The frequency drifts induced by DWI experiments were 5.1 ± 0.3 Hz/min during MRSI measurements on humans, resulting in increased spectral linewidth, significant bias in metabolite concentrations, and significantly increased Cramér-Rao lower bounds (P < 0.05). After prospective frequency corrections, the quality of MRSI was recovered to the level of those without any DWI-induced frequency drifts, judged by the spectral linewidth, metabolite concentrations, and Cramér-Rao lower bounds. CONCLUSION: The OVS-localized navigator demonstrated effective prospective frequency corrections for large frequency drifts (5 Hz/min) without introducing any saturation-induced SNR loss. These benefits can be particularly beneficial for the acquisition of MRS signals with long T(1) and/or short TR, and spectral editing.